Top News | POTUS eases self-driving regulations: Bloomberg reports that the White House will make it easier for companies to deploy self-driving cars to America’s roads, by creating special exceptions for automated vehicles. The US Department of Transportation will propose three new rules in an effort to modernize the Federal Motor Vehicle Safety Standards, relaxing some mandated features and amenities — like windshield wipers and defrosters — for driver-free vehicles. The agency feels that these “one-size-fits-all” rules no longer apply too all the vehicles, and the auto industry certainly isn’t going to complain. Switzerland joins the AI race: The open-source large language model Apertus (Latin for “open”) was released by a collective of Swiss public institutions, including the Swiss Federal Technology Institute of Lausanne, ETH Zurich, and the Swiss National Supercomputing Centre. Apertus is “completely open” — meaning the training materials, datasets, and documentation are all published and open for inspection, and were gathered according to Swiss data protection and copyright law. Switzerland hopes the idea of “public models” like this one catches on, transforming AI into something like a public utility rather than a privately-owned for-profit product. TurbineOne’s new customer is the US Army: The startup makes software that keeps soldiers informed and in touch in the field, without a steady cloud connection, by running locally on their drones, laptops, and smartphones. It’s a powerful enough idea to earn the San Francisco company a $98.9 million contract to provide their platform to the US Army. Typically, a four-year-old VC-funded startup with an innovative approach would have struggled to attract the DoD’s attention and operate within the Pentagon’s extended timelines, but the Trump Administration is looking to collaborate with more startups and expand the military’s arsenal of cutting-edge technologies. So look for more ambitious companies looking to take advantage of this trend.
| TWiST500 | It’s one of those days when we have more TWiST 500 news than stories about the biggest public tech companies. That’s a nice feeling… We’re obviously picking some winners if they’re making headlines THIS OFTEN. Anyway, let’s knock out these updates one at a time. | Stripe’s new blockchain: The fintech favorite has teamed with crypto-themed venture firm Paradigm on Tempo, a Layer-1 blockchain built specifically for stablecoins. While projects like Ethereum once focused exclusively on the application layer, making your own blockchain has become something of a hot trend. Rather than serving one native cryptocurrency, Tempo will accept a variety of stablecoins. A new Paradigm indeed. DeepSeek’s latest and greatest: The Chinese AI startup is apparently working on its own agentic features, to compete even more directly against US companies like OpenAI. The team reportedly plans to present their latest model — which can independently carry out multi-step real-world activities on behalf of human users — by the end of this year. Atlassian picks up The Browser Company: The startup was ahead of the curve on AI browsers, releasing Dia — with its built-in AI assistant — back in June. In fact, Perplexity reportedly considered buying them out before releasing their own rival, Comet. Instead, it’s SaaS giant Atlassian that sealed the deal, grabbing TBC for $610 million in hard cash. This makes a ton of sense, as most of Atlassian’s best-selling products — including the Jira project management suite — run in browsers. Inside Anthropic’s Frontier Red Team: Fortune took a look at the internal Anthropic group that stress-tests the company’s most advanced AI models, and tries to figure out how they might potentially be misused and abused by bad actors. (They’re particularly focused on national security, but also considering biological research, cybersecurity, and autonomy, among other dangers). As companies race to level up their models while keeping costs down, Anthropic continues to talk publicly about the importance of safety and good governance. Perhaps it’s a tactic but we’re not complaining. Nvidia funds Quantinuum: Finally, Nvidia — the chip maker and world’s most valuable company — took part in a $600 million new funding round, which values the quantum computing startup at $10 billion. The two companies already collaborate on Nvidia’s Accelerated Quantum Research Center in Boston. Multinational conglomerate Honeywell owns around 54% of Quantinuum and also participated in the new round. Ultimately, the promise here is that we’ll get extremely powerful computers capable of solving some of our most complex tasks, like designing new drugs, building more powerful AI models, and who knows, maybe getting us to Mars.
| A message from NetSuite | The business landscape is very chaotic right now. That’s why you need NetSuite, by Oracle. Download the CFO’s Guide to AI and Machine Learning for free at https://www.netsuite.com/twist | This Week in Startups | E2173: It’s a 70 minute plus autonomous driving deep dive on a brand new TWiST as Jason and Alex welcome Nuro co-founder and president Dave Ferguson. Together they unpack Nuro’s new mega-deal with Lucid and Uber, and look ahead to the arrival of fully driverless SUVs to Uber by next year. PLUS they’re evaluating claims that autonomous rides could one day be cheaper than driving a car, and look at ways to keep costs down, via high-tech chips, off-the-shelf sensors, and other hacks. | E2172: Jason and Alex are back with a packed new TWiST. First up, as humanoid robots become increasingly visible on our streets, and in our lives, is human vs. clanker violence INEVITABLE? Plus…. Apple’s open-source AI models have started to impress, triggering a rethink of the hardware giant’s position in the ongoing race. PLUS another hit model from Grok, Jason’s thoughts on the importance of curiosity, AND a chat with Runbin Dong of Scale Social about knowing your worth as a founder. | E2171: On an all-new TWiST, Jason, Alex, and Lon ponder the mega-success of Netflix’s “KPop Demon Hunters,” whether it will change the company’s strategy regarding theatrical releases, and how Sony — which produced the film, then sold it off for pennies on the dollar — missed out on a huge potential payday. PLUS Grok is counting on speed to outpace its rivals, Nvidia’s massive latest earnings report, and Polymarket attempts to predict the future of OpenAI. | TWiST Partner Offers | Lemon.io: Hire pre-vetted remote developers and get 15% off your first 4 weeks of developer time at https://Lemon.io/twist Northwest Registered Agent: Starting your business should be simple. With Northwest Registered Agent, you can form your entire business identity in just 10 clicks and 10 minutes. From LLCs to trademarks, domains to custom websites, they’ve got you covered. Get more privacy, more options, and more done—visit https://www.northwestregisteredagent.com/twist today! Stripe Startups: Stripe Startups offers early-stage, venture-backed startups access to Stripe fee credits, expert insights, and a focused community of builders. Apply today on stripe.com/startups.
| Angel University is Back! | Jason and Mike Savino are hosting our next virtual Angel University workshop on Tuesday, October 7. Jason will share proven strategies he’s used to invest $200M+ in over 500 startups. Whether you’re new to angel investing or looking to sharpen your skills, this is your chance to learn directly from one of the most active angel investors in the world. Register now at angel.university! | Founder U is Coming to the MENA Region! | Our 12-week pre-accelerator—designed to help early-stage founders build and grow—kicks off this fall in Saudi Arabia. The first cohort launches in Riyadh on November 3rd, followed by in-person and virtual sessions throughout the program. Founders in MENA: this is your chance to turn your idea into a business and get world-class insights on building a successful startup. Apply today: https://mena.founder.university/ | SF Live-Work Space Now Available | Need a flexible living and working environment in San Francisco? This thoughtfully designed loft-style residence at 787 Bryant St., the heart of the vibrant SOMA district and the city’s creative hub, is now available for rent or purchase. Check the listing for more details. | The TWiST500 newsletter is the new, updated, and improved TWiST Ticker. |
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