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US Edition - Today's top story: Huachuma, the Andean psychedelic cactus, is drawing Western seekers and raising ethical questions

September 8, 2026

US Edition

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Many Americans have been looking for healing in ancient traditions and reaching out for psychedelics. The latest to draw them is an Andean cactus, huachuma, better known as San Pedro.

Used for centuries in healing and spiritual ceremonies in South America, the plant contains mescaline, a psychoactive compound that alters perception and amplifies feelings of empathy and connection.

Pardis Mahdavi, a medical anthropologist who conducts research on psychedelics, interviewed hundreds of seekers over three years, from Arizona to Mexico to Costa Rica. As she writes, “Many came to huachuma after trying nearly everything else: talk therapy, antidepressants, silent retreats, other psychedelics.”

She cautions about both its safety and the ethics of its use, which include respecting the traditions and lineages surrounding huachuma. “The shamans I have interviewed hold clear, consistent beliefs about how to serve huachuma ethically, and for them the work begins long before anyone drinks,” she writes.

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Kalpana Jain

Senior Religion + Ethics Editor, Director of the Global Religion Journalism Initiative

 
Huachuma, an Andean cactus better known as San Pedro, has been used for centuries in healing ceremonies. Forest & Kim Starr via Wikimedia Commons

Huachuma, the Andean psychedelic cactus, is drawing Western seekers and raising ethical questions

Pardis Mahdavi, University of California, Berkeley

Huachuma, the Andean cactus better known as San Pedro, contains mescaline, a psychoactive compound that alters perception and mood.

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